H他利女还盟贵宜环垂联epatocyte影growthfactor,alsoknownasHGF,contains4kringledomains,
1PANdomainand1peptidaseS1钟染画往陆收内domain.Itbe民握居船longstothepeptidaseS1
family,plasminogensubfamily.Hepatocytegrowthfactorissecretedby
mesenchymalcellsasasingleinactivepolypeptideandis杂重宪声类脸发交考虽乱cleavedbyser航ine
proteasesintoa69-kDaalpha-chainand34白殖相酸备述落月-kDabeta-chain.Adisulfide
bondbetweenthealphaand据喜是块验夜志betachainsproducestheactive,
het强久父而耐到跑胶erodimericmolecule.H鲁题零传员皇epatocytegrowthfactorregulatescellgrowth,
cellmotility,andmorphogenes古顺局跟否争响即较isbyactivatingatyrosinekinasesignaling
casc便查确适写者景操喜置adeafterbindingtotheproto-oncogenicc-Metreceptor,andactsasa
multi-functi督亲坚块器粮立复onalcytokineoncellsofmainl吧家句精核歌庆回黑危yepithelialorigin.Itsa仍师掉儿复川河市bilityto
stimulatemito封侵许技呀衣权genesis,cel鲜否胡露丰滑贵望给势lmotility,andmatrixinvasiongivesitacentral
roleinangiogenesis,tumorogenesis,andtissueregeneration.HGFisa
potentmitogenformatureparenchymalhepatocytecells,seemstobean
hepatotrophicfactor,andactsasgrowthfactorforabroadspectrumof
tissuesandcelltypes.HGFhasnodetectableproteaseactivity.Defectsin
hepatocytegrowthfactorarethecauseofdeafnessautosomalrecessive
type39.Aformofprofoundprelingualsensorineuralhearingloss.
Sensorineuraldeafnessresultsfromdamagetotheneuralreceptorsofthe
innerear,thenervepathwaystothebrain,ortheareaofthebrainthat
receivessoundinformation.
标签：HGF
